I have *no earthly idea* whether the germ plasm is affected.
But I want to support as much organic horti/agriculture as I can, so I buy organic seeds when available and not TOO much more than conventional seeds.
Seed saving is also good, but where potatoes, carrots, and the like are concerned, I'm really not that into it. OTOH, I have absolute boatloads of rapini, komatsuna, lettuce (can't remember ATM the variety, but it was Seed Savers Exchange), and bok choy seeds.
2009 has been so physically difficult for me that we'll probably have to use plant starts all the way around for our first planting, and then seeds for the later plantings.
We still have a lot of seed from last year, due to our very small cultivated area (96 sq. ft.).
Sunset Zone 17, USDA Zone 9