Oh yes! A couple of times I tried growing this really cute little heirloom melon, only to go to the patch and find the deer had tried every single one. They ate the ripe ones and simply tasted the not quite ripe ones.
Groundhogs and raccoons will also eat ripe melons. One year we had a problem with the barn cats eating them!
As for the deer, I haven't done this but have read that it was tested extensively. Install a double fence. Google "deer double fence" for lots of info. Supposedly electric fencing works too but you can't do that easily in a neighborhood or with small children around. Although children do quickly learn to avoid the fence if they happen to get hold of it.